{"type":"standard","title":"Amyloid beta","displaytitle":"Amyloid beta","namespace":{"id":0,"text":""},"wikibase_item":"Q417667","titles":{"canonical":"Amyloid_beta","normalized":"Amyloid beta","display":"Amyloid beta"},"pageid":1958222,"thumbnail":{"source":"https://upload.wikimedia.org/wikipedia/commons/b/bb/Abeta_2lfm.jpg","width":220,"height":182},"originalimage":{"source":"https://upload.wikimedia.org/wikipedia/commons/b/bb/Abeta_2lfm.jpg","width":220,"height":182},"lang":"en","dir":"ltr","revision":"1285801850","tid":"56ceb9cc-1a43-11f0-9b86-f3f28df5075f","timestamp":"2025-04-15T21:48:17Z","description":"Group of peptides","description_source":"local","content_urls":{"desktop":{"page":"https://en.wikipedia.org/wiki/Amyloid_beta","revisions":"https://en.wikipedia.org/wiki/Amyloid_beta?action=history","edit":"https://en.wikipedia.org/wiki/Amyloid_beta?action=edit","talk":"https://en.wikipedia.org/wiki/Talk:Amyloid_beta"},"mobile":{"page":"https://en.m.wikipedia.org/wiki/Amyloid_beta","revisions":"https://en.m.wikipedia.org/wiki/Special:History/Amyloid_beta","edit":"https://en.m.wikipedia.org/wiki/Amyloid_beta?action=edit","talk":"https://en.m.wikipedia.org/wiki/Talk:Amyloid_beta"}},"extract":"Amyloid beta denotes peptides of 36–43 amino acids that are the main component of the amyloid plaques found in the brains of people with Alzheimer's disease. The peptides derive from the amyloid-beta precursor protein (APP), which is cleaved by beta secretase and gamma secretase to yield Aβ in a cholesterol-dependent process and substrate presentation. Both neurons and oligodendrocytes produce and release Aβ in the brain, contributing to formation of amyloid plaques. Aβ molecules can aggregate to form flexible soluble oligomers which may exist in several forms. It is now believed that certain misfolded oligomers can induce other Aβ molecules to also take the misfolded oligomeric form, leading to a chain reaction akin to a prion infection. The oligomers are toxic to nerve cells. The other protein implicated in Alzheimer's disease, tau protein, also forms such prion-like misfolded oligomers, and there is some evidence that misfolded Aβ can induce tau to misfold.","extract_html":"
Amyloid beta denotes peptides of 36–43 amino acids that are the main component of the amyloid plaques found in the brains of people with Alzheimer's disease. The peptides derive from the amyloid-beta precursor protein (APP), which is cleaved by beta secretase and gamma secretase to yield Aβ in a cholesterol-dependent process and substrate presentation. Both neurons and oligodendrocytes produce and release Aβ in the brain, contributing to formation of amyloid plaques. Aβ molecules can aggregate to form flexible soluble oligomers which may exist in several forms. It is now believed that certain misfolded oligomers can induce other Aβ molecules to also take the misfolded oligomeric form, leading to a chain reaction akin to a prion infection. The oligomers are toxic to nerve cells. The other protein implicated in Alzheimer's disease, tau protein, also forms such prion-like misfolded oligomers, and there is some evidence that misfolded Aβ can induce tau to misfold.
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{"slip": { "id": 143, "advice": "When painting a room, preparation is key. The actual painting should account for about 40% of the work."}}
{"slip": { "id": 213, "advice": "Quality beats quantity."}}
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